Dr. Pat Olson, Gloria Reed, and Don Reed
Gloria, my wife of 48 years, was walking down the street toward me.
But something was wrong. Her face was gray. She said she had pain in her back and chest. One arm felt heavy, and she had broken out in a cold sweat.
It took some doing, but last she was safe and snug in a hospital bed in the emergency room. There was a needle in the back of her hand, wires taped to her chest, an oxygen clip in her nose, as well as the background beep of electronic monitors, the squeak of nurses’ ripple-soled shoes—
“I’m bored,” said Gloria.
Heart attack. The number one cause of death in America—claiming approximately one million lives every year.
Some have heart conditions that are not immediately fatal, but which put their owners at risk.
The American Heart Association estimates that 5.7 million Americans suffer from heart failure. Cardiovascular disease costs our country an estimated $286 billion in direct (out of pocket) and indirect (time lost from work) expenses.
Heart transplants are practical; the only problem is, there are not enough spare hearts to fill the need.
Former Vice President Dick Cheney had to wait 20 months for a transplanted heart. At last a suitable replacement heart was found, and his life continues today.
Might there be a stem cell answer? Joseph Wu is trying to find out. Working with Deepak Srivastava of the Gladstone Institute and Wolfram Zimmerman of the University Medical Center at Goettingen in Germany, Dr. Wu is battling to find ways to repair the damage left by a heart attack.
Their weapon is tissue engineering, which involves the development of biological substitutes to restore, maintain, or improve the functioning of a body part.
Dr. Joseph Wu is working to develop a stem cell “tire patch” for damaged hearts.
Dr. Wu said: “Our proposal seeks to use…tissue patches seeded with human embryonic stem cell-derived cardiomyocytes (heart cells for treatment heart disease) in small and large animals…”
Have you ever fixed a flat tire on a bicycle, and had to glue on a rubber patch?
Tissue engineering may work similarly, except the patch becomes part of the patient.
As quoted from his fund request statement, Dr. Wu said: “Novel therapies with stem cells in combination with supportive scaffolds (are emerging as a promising) avenue. Engineered tissues have now been used to make new bladders for patients… and more recently new trachea (in the throat—DR) for patients with late stage tracheal cancer.
“Our team intends to push the envelope by developing human tissue-engineered myocardium—heart muscle for treatment (after) heart failure.
“...we are confident we will be able to derive a lead candidate that can move into…preclinical development. These discoveries will benefit millions of patients with heart failure in California and globally.”
“I found no evidence of lasting damage,” the doctor said.
We had dodged a bullet.
With proper diet and exercise, my angel will be free to harass her husband for years to come.
Title: California Cures! How the California Stem Cell Program is Fighting Your Incurable Disease!
Author: Don C. Reed
Genre: Medicine, Stem Cell Research, Sciences
Thirteen years ago, America faced an epidemic of chronic disease: cancer, paralysis, blindness, arthritis, Alzheimer's disease, diabetes and more.
But California voters said "YES!" to a $3 billion stem cell research program: the awkwardly-named California Institute for Regenerative Medicine (CIRM). Born into battle, the scrappy little state agency was immediately blocked by three years of anti-science lawsuits — but it defeated them all. And then?
A quiet triumph. With a focused intensity like the Manhattan Project (but for peaceful purposes, not to build a bomb), scientists funded by CIRM took on the challenges: disease and disability called chronic: incurable.
In a series of connected stories, accurate though written to entertain, "California Cures" relates a war: science against disease, with lives on the line. Think what it means for a paralyzed young man to recover the use of his hands, or for a formerly-blind mother to see her teenaged children — for the first time!
Do you know the "bubble-baby" syndrome? Infants without a proper immune system typically die young; a common cold can kill. But for eighteen babies in a stem cell clinical trial, a different future: they were cured of their disease.
No one can predict the pace of science, nor say when cures will come; but California is bringing the fight. The reader will meet the scientists involved, the women and men behind the microscope, and share their struggle.
Above all, "California Cures" is a call for action. Washington may argue about the expense of health care (and who will get it), but California works to bring down the mountain of medical debt: stem cell therapies to ease suffering, and save lives.
Will California build on success — and invest $5 billion more in stem cell research?
"We have the momentum", says author Don C Reed, "We dare not stop short. Chronic disease threatens everyone — we are fighting for your family, and mine!"
Introduction: Evangelina and the Golden State
The Absolute Minimum You Need to Know First
To Breathe, or Not to Breathe
The Strongest Man in the World
When the Dolphin Broke My Ear
The Boy with Butterfly Skin
The Great Baldness "Comb-Over" Replacement?
"He Sees! He Sees!"
Cop at the Window
"Go West, Young (Wo)Man" — To a Biomed Career?
And How Will You be Paying for that New Heart?
The Answer to Cancer?
A Political Obstacle to Heart Disease Cure?
Your Friend, the Liver!
"Bring 'em Back Alive"
The Color of Fat
Revenge for My Sister
A Story with No Happy Ending?
Aging and Stem Cells
The "Impending Alzheimer's Healthcare Disaster"
President Trump's Great Stem Cell Opportunity
Leiningen's Ants and Parkinson's Disease
On the Morality of Fetal Cell Research
Democracy and Gloria's Knees
Three Children, and the Eternal Flame
Autism, Mini-Brains, and the Zika Virus
Why "The Big Bang Theory" Matters to Me
Musashi and the Two-Sword Solution
"The Magnificent Seven"
The Connecticut Commitment
In Memory of Beau
To Relocate Alligators, or Turn a Country on to Biomed?
Whale Sharks and Outer Space
Mr Science Goes to Washington?
When Oklahoma is Not OK
James Bond and Melanoma
Neurological Diseases vs. California
Driving to the Storm
Door into Tomorrow
Stem Cell Battles — On Times Square?
Annette, Richard Pryor, and Multiple Sclerosis
Mike Pence, and Reproductive Servitude
Motorcycle Wrecks and Complex Fractures
Even Dracula Gets Arthritis
Tugboat for Cure
Wheelchair Warriors, Take Back Your Rights!
Sickle Cell Disease vs. Stem Cell Agency
Dwight Clark, "The Catch," and A L S
A Friend is Lost
Dying in Doonesbury, Fighting Back at UCD
The Man with the Autographed Baseball
The Gorilla Gynecologist Returns
Wrestling the Invisible Enemy
Two Warriors Named Joan
An End to Heroism?
Message from the Middle Kingdom
Scientists and the Undocumented
The Girl, the Bandit, and Women in Science
The Greatest Proposal
Forty-Two California Clinical Trials
Gathering of Champions